Several limitations prevent the implementation of the ideal Cost Benefit Analysis process where data is limited:
Difficulty of establishing a dose-response or exposure-response function for health impacts due to POPs: despite the recognized link between POPs exposure and health impacts, establishing an unequivocal relationship between POPs-exposure and adverse health impacts has yet evaded scientists (Herkovits, 1998). There is no available exposure-response or dose-response equation that would allow us to derive a quantitative estimate of a disease incidence (and severity) in the population from its level of exposure to, or contamination by, POPs.
Difficulty of estimating the reduction in exposure achieved through a risk management scenario: the multiple exposure pathways between the environment and human population make it difficult to draw a quantitative link between the risk management scenario and exposure reduction.
Limited data and knowledge gathering: in most developing countries, data are not available and the cost of data collection is economically prohibitive.
In consideration of these points, the ideal approach needs to be redefined or adapted. Therefore a refined and simplified methodology was developed in order to proceed with the economic analysis.
Next: Adapted Methodology
 “Although several studies seem to indicate a dose-response ratio for POPs […], it seems irresponsible to suggest a threshold concentration for adverse effects of these substances” (Herkovits, 1998). http://www.chem.unep.ch/pops/POPs_Inc/proceedings/Iguazu/herkovits.html