Health Canada toxicity reference values (TRVs) may be applied where available (Health Canada, 2004). These are referred to as tolerable daily intake (TDI) or reference dose values for non-carcinogens, and slope factors (SF) for carcinogens.
Data without Health Canada TRVs
For substances with no Health Canada TRVs, Reference Doses (RfDs), Reference Concentrations (RfCs), Acceptable Daily Intakes (ADIs), Minimum Risk Levels (MRLs) or Cancer Slope Factors (CSFs) should be obtained from the following agencies, in order of preference (Health Canada 2004):
- U.S. EPA Integrated Risk Information System (IRIS):
- World Health Organization (WHO)
- Netherlands National Institute of Public Health and the Environment (RIVM):
- Agency for Toxic Substances and Disease Registry (ATSDR) (U.S.);